What are the signs and symptoms of postpolio progressive muscular atrophy?

Updated: Feb 20, 2018
  • Author: Sridharan Ramaratnam, MD, MBBS; Chief Editor: Helmi L Lutsep, MD  more...
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Answer

Clinical features include the following:

  • Fatigue and loss of independence in activities of daily living (ADLs)

  • Development of new-onset asymmetric weakness and/or atrophy in muscles that were affected previously or were unaffected by polio

  • New onset or worsening of muscle twitching or cramping

  • Pain

  • Pyramidal signs distinctly lacking

  • Bulbar features, such as dysphagia and dysphonia, seen only as residua among patients who showed such involvement in the disease's acute stage

  • Progression much slower than in classical ALS

  • Postpolio syndrome patients with predominant fatigue may form a subgroup who are younger, had shorter polio duration, more pain, higher body mass index, lower quality of life, and more physical and mentally fatigue. [23]


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