What is the global prevalence of focal muscular atrophy (FMA)?

Updated: Feb 20, 2018
  • Author: Sridharan Ramaratnam, MD, MBBS; Chief Editor: Helmi L Lutsep, MD  more...
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Answer

For the same reasons outlined for the US, incidence and prevalence data are not available. Even for the individual diseases, considerable geographic variation exists. A population-based study revealed a PPMA prevalence of 92 per 100,000 population in a Swedish county. [3] The prevalence of post-polio syndrome in Kitakyushu, Japan was 18 per 100,000 population. [4] The frequencies of PPMA among survivors of polio in other countries (not community-based studies) are 60% in the Netherlands [5] , 58% in Norway [6] , 68% in Germany, and 22% in India [7] . An estimated 3000-5000 persons with PPMA reside in New Zealand. [8] These figures are likely to be overestimated. [9]

Many of the infectious causes of FMA (eg, polio, leprous neuropathy) are more frequent in developing countries.

Monomelic amyotrophy has been reported more often in India [10] , Korea [11] , and Japan than in other countries. In a hospital-based study from India, among 110 patients with anterior horn cell disease, 10.9% had progressive muscular atrophy; 1.8%, PPMA; and 22.7%, monomelic amyotrophy. [12]


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