Which medications in the drug class Antidepressant, Tricyclic are used in the treatment of Diabetic Neuropathy?

Updated: Jan 08, 2019
  • Author: Dianna Quan, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

Antidepressant, Tricyclic

For paresthetic pain, tricyclic antidepressants such as imipramine (Tofranil), nortriptyline (Pamelor, Aventyl), and amitriptyline (Elavil) have been shown to be useful as analgesics for paresthetic pain. [105]

Amitriptyline (Elavil)

By inhibiting reuptake of serotonin and/or norepinephrine by presynaptic neuronal membrane, may increase synaptic concentration in CNS. Useful as analgesic for certain types of chronic and neuropathic pain.

Imipramine (Tofranil)

This is the original TCA used for depression. These agents have been suggested to act by inhibiting reuptake of norepinephrine at synapses in central descending pain modulating pathways located in the brainstem and spinal cord.

Nortriptyline (Pamelor, Aventyl HCl)

Has demonstrated effectiveness in treatment of chronic pain; by inhibiting reuptake of serotonin and/or norepinephrine by presynaptic neuronal membrane, may increase synaptic concentration in CNS; pharmacodynamic effects such as desensitization of adenyl cyclase and down-regulation of beta-adrenergic receptors and serotonin receptors also appear to be involved in mechanisms of action.


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