Which medications in the drug class Analgesic, Topical are used in the treatment of Diabetic Neuropathy?

Updated: Jan 17, 2020
  • Author: Dianna Quan, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Analgesic, Topical

Identifying the type of pain can direct the course of therapy. Dysesthetic pain can be relieved with capsaicin cream (Dolorac, Capsin, Zostrix) applied qid. Capsaicin cream may cause pain during the initial few applications; patients need to be made aware of this potential effect. Additionally, few patients comply with the frequent dosing, and the cream is messy on socks and shoes. Several recent studies have advocated topical administration of lidocaine as treatment of postherpetic neuralgia. Lidocaine gel (5%) in placebo-controlled study showed significant relief in 23 patients studied. Lidocaine tape also decreases severity of pain.

Capsaicin cream (Zostrix)

Natural chemical derived from plants of Solanaceae family. By depleting and preventing reaccumulation of substance P in peripheral sensory neurons, may render skin and joints insensitive to pain. Substance P thought to be chemomediator of pain transmission from periphery to CNS.

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