Which medications in the drug class Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are used in the treatment of Diabetic Neuropathy?

Updated: Jan 17, 2020
  • Author: Dianna Quan, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

In patients with acute painful neuropathy, simple analgesics such as nonsteroidal anti-inflammatory drugs [NSAIDs] and acetaminophen may provide pain control. [104] They also may be used as first-line therapy in painful peripheral neuropathy. With chronic painful neuropathy, simple analgesics are typically not effective. More often, chronic neuropathic pain requires treatment with off-label medications.

Ibuprofen (Advil, Motrin IB)

NSAIDs may help decrease inflammation caused by diabetic neuropathy. They also decrease pain.

Naproxen (Naprosyn)

For relief of mild-to-moderate pain; inhibits inflammatory reactions and pain by decreasing activity of cyclo-oxygenase, which results in a decrease of prostaglandin synthesis.

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