What are the differences in efficacy between gabapentin and tricyclic antidepressants for the treatment of diabetic neuropathic pain?

Updated: Jan 08, 2019
  • Author: Dianna Quan, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

There was no difference identified between gabapentin and tricyclic antidepressants in the achievement of pain relief of diabetic neuropathy or postherpetic neuralgia in a study by Chou et al. The authors performed a meta-analysis of head-to-head trials comparing the results of gabapentin and tricyclic antidepressants for pain relief in diabetic neuropathy. [84] . Pregabalin has similar efficacy as gabapentin for most part.


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