What is the role of duloxetine in the treatment of diabetic neuropathy?

Updated: Jan 17, 2020
  • Author: Dianna Quan, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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In a review of 6 trials (2220 patients) on duloxetine's effects on painful diabetic peripheral neuropathy (3 trials) and fibromyalgia (3 trials), Lunn et al concluded that 60 mg of duloxetine daily can relieve the pain of peripheral neuropathy in the short-term, calculating a 1.65 risk ratio for a 50% pain reduction at 12 weeks. [85] Adverse events were common and dose dependent, according to the authors, but serious ones were rare. The 2011 AAN/AANEM/AAPMR guideline recommends considering the antidepressants amitriptyline, venlafaxine, and duloxetine for the treatment of PDN, although data are insufficient to recommend one of these agents over the others.

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