What is the role of skin biopsy in the diagnosis of diabetic neuropathy?

Updated: Jan 17, 2020
  • Author: Dianna Quan, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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A skin biopsy can be obtained for research purposes only. Immunohistochemistry is used to quantify the cutaneous nerves to provide a morphologic assessment of diabetic neuropathies. This tool is new for clinical research, and it is used as an endpoint in diabetic neuropathy. The procedure requires only a 3-cm skin biopsy and enables a direct study of small nerve fibers (ie, C-fibers) that produce pain and temperature sensation.

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