What is the role of nuclear imaging in the diagnosis of diabetic neuropathy?

Updated: Jul 23, 2019
  • Author: Dianna Quan, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

Scintigraphic techniques are used to detect and quantify cardiac autonomic neuropathy (for research purposes). Techniques include radiolabeled analogs of norepinephrine, 123I-metaiodobenzylguanidine (MIBG), and 11C-hydroxyephedrine. Adrenergic nerve terminals of the heart actively take up these compounds. Combining this technique with single-photon emission computed tomography (SPECT) scanning allows detection of decreased innervation of the heart.


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