What is the accuracy of screening tools used for diabetic neuropathy?

Updated: Jan 17, 2020
  • Author: Dianna Quan, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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In a systematic review of 5 studies of noninvasive screening tools for detecting peripheral neuropathies in pediatric patients with type 1 diabetes, Hirschfeld and colleagues found that the diagnostic utility of the Rydel-Seiffer tuning fork and 10-g Semmes-Weinstein monofilament was low, while that of biothesiometry and a finer (1-g) monofilament was acceptable. Sensitivities and specificities of these screening tools were as follows: [66, 67]

  • Tuning fork: 87-99% (sensitivity); 1-19% (specificity)

  • Coarse monofilament: 16% (sensitivity); 64% (specificity)

  • Fine monofilament: 73% (sensitivity); 87% (specificity)

  • Biothesiometer: 61-80% (sensitivity); 64-76% (specificity)

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