What is diabetic neuropathic cachexia?

Updated: Jan 08, 2019
  • Author: Dianna Quan, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

In diabetic neuropathic cachexia, the patient experiences a precipitous and profound weight loss followed by severe and unremitting cutaneous pain, small-fiber neuropathy, and autonomic dysfunction. This condition occurs more often in older men; impotence is common. Muscle weakness is uncommon. The condition usually improves with prolonged glycemic control; however, symptoms are often refractory to other pharmacologic treatment. Limited anecdotal improvement is reported with nonpharmacologic treatments such as sympathectomy, spinal cord blockade, and electrical spinal cord stimulation. Recovery may be incomplete and prolonged over many months


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