What is small-fiber diabetic neuropathy?

Updated: Jan 17, 2020
  • Author: Dianna Quan, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Small-fiber neuropathy is a distal symmetrical neuropathy involving predominantly small-diameter sensory fibers (A delta and C fibers). It manifests as painful paresthesias that patients perceive as burning, stabbing, crushing, aching, or cramplike, with increased severity at night. There is loss of pain and temperature sensation with relative sparing of distal reflexes and proprioception.

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