What is the role of advanced glycation end products (AGEs) in the pathophysiology of diabetic neuropathy?

Updated: Jan 08, 2019
  • Author: Dianna Quan, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
  • Print
Answer

The nonenzymatic reaction of excess glucose with proteins, nucleotides, and lipids results in advanced glycation end products (AGEs) that may have a role in disrupting neuronal integrity and repair mechanisms through interference with nerve cell metabolism and axonal transport. [17]


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!