What are the subdivision of sensory neurons in diabetic neuropathy?

Updated: Jan 08, 2019
  • Author: Dianna Quan, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

The smaller fibers are affected first in DM. With continued exposure to hyperglycemia, the larger fibers become affected. Fibers of different size mediate different types of sensation, as shown in the table below.

Table. Subdivisions of Sensory Neurons (Open Table in a new window)

Fiber Type

Size

Modality

Myelination

A-alpha (I)

13-20 micrometers

Limb proprioception

Yes

A-beta (II)

6-12 micrometers

Limb proprioception, vibration, pressure

Yes

A-delta (III)

1-5 micrometers

Mechanical sharp pain

Yes

C (IV)

0.2-1.5 micrometers

Thermal pain, mechanical burning pain

No


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