What is the anatomy of sensory neurons in diabetic neuropathy?

Updated: Jan 08, 2019
  • Author: Dianna Quan, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

Sensory neurons originate at the dorsal root ganglia (which lie outside the spinal cord) and follow a similar course with motor neurons. Sensory neurons are subdivided into categories according to the sensory modality they convey (see the Table below).

Table. Subdivisions of Sensory Neurons (Open Table in a new window)

Fiber Type

Size

Modality

Myelination

A-alpha (I)

13-20 micrometers

Limb proprioception

Yes

A-beta (II)

6-12 micrometers

Limb proprioception, vibration, pressure

Yes

A-delta (III)

1-5 micrometers

Mechanical sharp pain

Yes

C (IV)

0.2-1.5 micrometers

Thermal pain, mechanical burning pain

No


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