What is the association between neurosyphilis and HIV infection?

Updated: Jul 17, 2018
  • Author: Richard P Knudsen, MD, FAAN, FAAP; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Syphilis and HIV are frequently found in the same patient, given the epidemiologic risk factors. Thus, each should be tested for after receiving consent. CSF abnormalities in patients with the concomitant infections include a higher protein content and more impressive pleocytosis. Additionally, the response to treatment is less pronounced. Therapeutically, some authors purport that highly active antiretroviral therapy to reverse immunosuppression from HIV may help mitigate neurologic complications of syphilis. [14, 37, 38, 39, 40, 41, 42, 43]

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