What causes the tertiary lesions of neurosyphilis?

Updated: Jul 17, 2018
  • Author: Richard P Knudsen, MD, FAAN, FAAP; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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The various manifestations of syphilis are time dependent. Syphilis is classified as primary, secondary, tertiary, or quaternary. Tertiary (ie, late) lesions are caused by obliterative small vessel endarteritis, which usually involves the vasa vasorum of the CNS. Factors that determine the development and progression of tertiary disease are not known.

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