When is operative brain biopsy indicated in the diagnosis of viral meningitis?

Updated: Jul 17, 2018
  • Author: Cordia Wan, MD; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Operative brain biopsy for confirmation of herpetic encephalitis largely has been replaced by PCR testing for viral DNA. In some cases, however, encephalomalacia due to an unknown viral infection may be confused with vascular infarction or, rarely, a tumor; in these cases, a biopsy may be helpful. With the use of stereotactic localization and a needle biopsy, morbidity is minimal.

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