What treatment addresses the pathophysiologic causes of alcoholic ketoacidosis (AKA)?

Updated: Aug 27, 2020
  • Author: George Ansstas, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

Treatment of alcoholic ketoacidosis (AKA) is directed toward reversing the three major pathophysiologic causes of the syndrome, which are:

  • Extracellular fluid volume depletion

  • Glycogen depletion

  • An elevated ratio of the reduced form of nicotinamide adenine dinucleotide (NADH) to nicotinamide adenine dinucleotide (NAD+)

This goal can usually be achieved through the administration of dextrose and saline solutions. [5]


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