What is the efficacy of tricyclic antidepressants (TCAs) in the treatment of HIV-associated distal painful sensorimotor polyneuropathy?

Updated: Aug 08, 2019
  • Author: Florian P Thomas, MD, PhD, MA, MS; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
  • Print


Tricyclic antidepressants (TCAs) are widely used for painful paresthesias. Nevertheless, amitriptyline was not significantly more effective than placebo in relieving pain caused by HIV-related peripheral neuropathy. [30]

While dosages of various TCAs are similar, drugs in this category vary in their sedative properties. Amitriptyline can be used if the patient suffers from insomnia, while nortriptyline and desipramine are better choices when sedation becomes a problem.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!