What is the efficacy of anticonvulsants in the treatment of HIV-associated distal painful sensorimotor polyneuropathy?

Updated: Aug 08, 2019
  • Author: Florian P Thomas, MD, PhD, MA, MS; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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gabapentin-343011">Gabapentin was found to be more effective than placebo in reducing pain and sleep interference in patients with painful HIV-associated sensory neuropathies. [27]  It is usually well tolerated, with a wide dose range. Drug levels are not available, indicated, or meaningful.

Lamotrigine was well tolerated and effective for HIV-associated neuropathic pain in patients receiving neurotoxic antiretroviral therapy, but not in patients not receiving such drugs. [28]

Pregabalin and duloxetine have shown success in diabetic neuropathy. In a study by Simpson et al, however, pregabalin did not significantly improve pain compared with placebo for painful HIV-associated neuropathy. [29]


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