What is HIV-associated distal painful sensorimotor polyneuropathy?

Updated: Aug 08, 2019
  • Author: Florian P Thomas, MD, PhD, MA, MS; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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A distal painful sensorimotor polyneuropathy is the most common type of HIV-1 associated peripheral neuropathy. [1, 2, 3] It usually develops during late HIV infection; it is rare in otherwise healthy seropositive patients. HIV-associated distal painful neuropathy is a progressive disease unless co-existant causes, such as neurotoxic drugs or vitamin deficiencies, can be eliminated. [5] HIV-associated distal sensorimotor polyneuropathy is the most common neurologic complication of HIV infection. [6, 7] It must be distinguished from neuropathy associated with neurotoxic anti-retroviral agents.

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