Which clinical history findings are characteristic of CNS cryptococcosis in HIV infection?

Updated: Jan 08, 2020
  • Author: Felicia J Gliksman, DO, MPH; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
  • Print


Disease onset is usually insidious, which may be why the time from symptom onset to diagnosis is, on average, 30 days or more. The delay also may be due to the waxing-and-waning course and the nonspecificity of symptoms.

Onset is rarely fulminant. Lung involvement is found in fewer than one third of patients with CNS cryptococcosis. Occasionally, evidence of unsuspected CNS cryptococcosis is detected on cerebrospinal fluid analysis done for other reasons. In almost half of patients, cryptococcosis in the CNS or elsewhere is the AIDS-defining illness.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!