Which histologic findings are characteristic of CNS toxoplasmosis in HIV infection?

Updated: Jul 11, 2017
  • Author: Gulshan Uppal, MD; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Answer

Answer

Histologic findings include the following (also see the images below):

  • Lymphocytic meningitis, individual cyst-containing lesions

  • Astroglial and microglial nodules

  • Associated lymphocytic vasculitis

  • Diffuse encephalitis

Toxoplasma gondii abscesses are seen on this brain Toxoplasma gondii abscesses are seen on this brain slice. Contributed by Dr Beth Levy, Saint Louis University School of Medicine, St Louis, Missouri.
High-magnification photomicrograph shows a tissue High-magnification photomicrograph shows a tissue cyst and tachyzoites in the brain parenchyma. Contributed by Dr Beth Levy, Saint Louis University School of Medicine, St Louis, Missouri.

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