What is the pathophysiology of CNS toxoplasmosis in HIV infection?

Updated: Jul 11, 2017
  • Author: Gulshan Uppal, MD; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Answer

Answer

CNS toxoplasmosis results from infection by the intracellular parasite Toxoplasma gondii. It is almost always due to reactivation of old CNS lesions or to hematogenous spread of a previously acquired infection. [1] Occasionally, it results from primary infection.

CNS disease occurs during advanced HIV infection when CD4+ counts are less than 200 cells/µL. The greatest risk is in patients with CD4+ counts below 50 cells/µL. [1]


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