What is the role of ganciclovir and foscarnet in the treatment of cytomegalovirus (CMV) encephalitis in HIV?

Updated: Jul 25, 2017
  • Author: Gulshan Uppal, MD; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Answer

Answer

Ganciclovir and foscarnet are indicated for CMV infections in the induction phase. The 2 agents may be used in combination, although this combination results in substantial rates of adverse effects. [4, 3] Long-term intravenous (IV) maintenance therapy may be indicated for patients who have a clinical response.

Suggested dosing: IV gancyclovir (5 mg/kg every 12 hours) plus foscarnet (90 mg/kg every 12 hours). [8]


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