What is the main pathophysiological mechanism of Ramsay Hunt syndrome?

Updated: Jul 16, 2018
  • Author: Sombat Muengtaweepongsa, MD, MSc; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Answer

After chickenpox, VZV remain latent in neurons of cranial nerve and dorsal root ganglia. Subsequent reactivation of latent VZV can result in localized vesicular rash, known as herpes zoster. VZV infection or reactivation involving the geniculate ganglion of CN VII within the temporal bone is the main pathophysiological mechanism of Ramsay Hunt syndrome. Diminished level of VZV-specific cell-mediated immunity may lead to reactivation of this virus. [4]


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