Which medications in the drug class Vaccines are used in the treatment of Meningococcal Meningitis?

Updated: Jul 16, 2018
  • Author: Francisco de Assis Aquino Gondim, MD, PhD, MSc, FAAN; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Answer

Vaccines

Meningococcal vaccines may be used to prevent and control outbreaks of serogroup C meningococcal disease according to CDC guidelines. They induce the formation of bactericidal antibodies to meningococcal antigens. They are used for active immunization against invasive meningococcal disease caused by inclusive serogroups.

Menactra is used for active immunization for persons aged 2-55 years for the prevention of invasive meningococcal disease. Menomune is approved for use in persons of aged 2 years and older and is the preferred vaccine for aged 56 years or older. Menveo is approved in persons aged 9 months to 55 years. A combination vaccine (MenHibrix) is also available. These vaccines do not prevent N meningitidis serogroup B infections.

In October 2014, the FDA approved the first vaccine for active immunization to prevent invasive meningococcal disease caused by N meningitidis serogroup B in individuals aged 10 through 25 years. [18] A second vaccine for serogroup B was approved in January 2015. [26]

Meningococcal A C Y and W-135 polysaccharide vaccine combined (Menomune A/C/Y/W-135)

Meningococcal vaccines may be used to prevent and control outbreaks of serogroup C meningococcal disease according to CDC guidelines. They induce the formation of bactericidal antibodies to meningococcal antigens. It is used for active immunization against invasive meningococcal disease caused by inclusive serogroups.

Meningococcal A C Y and W-135 diphtheria conjugate vaccine (Menactra, Menveo)

This vaccine is indicated for children as young as 9 months (Menactra) or 2 months (Menveo) and adults up to 55 years.

Meningococcal C and Y/haemophilus influenza type B vaccine (MenHibrix)

Menhibrix is a combination vaccine approved for use in children as young as 6 weeks old and is indicated to prevent invasive disease caused by Neisseria meningitides serogroups C and Y, and Haemophilus influenzae type b. Menhibrix was newly approved in 2012 and is a 4-dose sequence.

Meningococcal group B vaccine (Trumenba, Bexsero)

The vaccine is administered as a 3-dose series at months 0, 2, and 6 (Trumenba) or a 2-dose series given at least 1 month apart (Bexsero). It induces production of bactericidal antibodies directed against the capsular polysaccharides of serogroup B. It is indicated for active immunization to prevent invasive meningococcal disease caused by Neisseria meningitidis serogroup B in individuals aged 10 through 25 years.


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