Which medication regimen is recommended for neonatal herpes simplex encephalitis (HSE)?

Updated: Jul 17, 2018
  • Author: Wayne E Anderson, DO, FAHS, FAAN; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Answer

Acyclovir in doses of 20 mg/kg IV every 8 hours (60 mg/kg/d) is currently recommended for neonatal HSE. This dosage is higher than that used in older children and adults (30 mg/kg/d), but, in neonates, it has been shown to improve mortality and morbidity when compared with the lower dosage. Because the higher dosage is associated with neutropenia, the white blood cell (WBC) count should be monitored closely.


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