When is lumbar puncture indicated in the diagnosis of herpes simplex encephalitis (HSE)?

Updated: Jul 17, 2018
  • Author: Wayne E Anderson, DO, FAHS, FAAN; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Once a space-occupying lesion has been excluded by imaging, lumbar puncture always should be performed in suspected HSE. In general, CSF yield is proportional to the volume analyzed; an adequate volume of CSF should be obtained (>10 mL).

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