What is the disease course of untreated herpes simplex encephalitis (HSE)?

Updated: Jul 17, 2018
  • Author: Wayne E Anderson, DO, FAHS, FAAN; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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A vivid description of the temporal course of tissue destruction is given in an immunohistologic autopsy study of patients succumbing to HSE over periods of days to weeks in the era prior to acyclovir: The impression is of a rapidly spreading wave of viral infection within limbic structures, probably starting on one side of the brain and spreading within it and to the other side, lasting about 3 weeks and resulting in severe necrosis and inflammation in infected parts of the brain. [12]

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