Which medications are used in the treatment of herpes simplex encephalitis (HSE)?

Updated: Jul 17, 2018
  • Author: Wayne E Anderson, DO, FAHS, FAAN; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Medications used in the management of HSE include the following:

  • Antivirals (eg, acyclovir, famciclovir): Drug of choice for HSE; to shorten the clinical course, prevent complications, prevent development of latency and subsequent recurrences, decrease transmission, and eliminate established latency

  • Anticonvulsants (eg, carbamazepine, phenytoin): To terminate clinical and electrical seizure activity as rapidly as possible and to prevent seizure recurrence

  • Diuretics (eg, furosemide, mannitol): To manage increased intracranial pressure in complications resulting from HSE

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