Which procedures are performed in the workup of herpes simplex encephalitis (HSE)?

Updated: Jul 17, 2018
  • Author: Wayne E Anderson, DO, FAHS, FAAN; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Answer

Lumbar puncture for CSF analysis

PCR assay of CSF for HSV-1 and HSV-2: Essentially replaced brain biopsy as the criterion standard for diagnosis [7, 8]

Brain biopsy: Diminishing role; rarely used in current practice for either confirming diagnosis of HSE or establishing alternative diagnoses

Viral CSF cultures are rarely positive and should not be relied on to confirm the diagnosis. However, HSV can be cultured from the CSF in about one third of affected neonates.

See Workup for more detail.


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