How does herpes simplex encephalitis (HSE) differ in neonates?

Updated: Jul 17, 2018
  • Author: Wayne E Anderson, DO, FAHS, FAAN; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Answer

HSE occurs as 2 distinct entities:

  • In children older than 3 months and in adults, HSE is usually localized to the temporal and frontal lobes and is caused by HSV-1

  • In neonates, however, brain involvement is generalized, and the usual cause is HSV-2, which is acquired at the time of delivery


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