What are clinical findings indicative of herpes simplex encephalitis (HSE)?

Updated: Jul 17, 2018
  • Author: Wayne E Anderson, DO, FAHS, FAAN; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Answer

There are no pathognomonic clinical findings associated with HSE. Focal neurologic deficits, CSF pleocytosis, and abnormalities on CT scanning may be absent initially. Therefore, a high index of suspicion is required to make the diagnosis, particularly in immunocompromised patients with febrile encephalopathy. Expeditious evaluation is indicated after the diagnosis of HSE is considered.


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