Which medications in the drug class Anticonvulsants are used in the treatment of Haemophilus Meningitis?

Updated: Jul 09, 2018
  • Author: Prateek Lohia, MD, MHA; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Answer

Anticonvulsants

Seizures that occur on presentation and during the earliest acute phase of Hib meningitis do so because of transient focal derangements in the cortex or because of metabolic disturbances such as hyponatremia or hypoglycemia. Treatment may require the administration of anticonvulsants, the choice of which involves consideration of the type of seizures, the age of the patient, and the route of drug administration.

Carbamazepine (Tegretol, Tegretol XR)

The anticonvulsant action of carbamazepine may involve depressing activity in the nucleus ventralis anterior of thalamus, resulting in reduction of polysynaptic responses and blocking of posttetanic potentiation. It reduces sustained high-frequency repetitive neural firing.

Lamotrigine (Lamictal, Lamictal XR, Lamictal ODT)

Lamotrigine is a triazine derivative that is effective as an adjunctive and primary drug in the management of partial seizures, generalized seizures, and neuralgia. It inhibits the release of glutamate and inhibits voltage-sensitive sodium channels, leading to stabilization of the neuronal membrane.

Topiramate (Topamax)

Topiramate is a sulfamate-substituted monosaccharide with a broad spectrum of antiepileptic activity that may have a state-dependent sodium channel blocking action, potentiating the inhibitory activity of the neurotransmitter gamma-amino butyric acid (GABA). It may block glutamate activity.

Gabapentin (Neurontin)

Gabapentin is a membrane stabilizer, a structural analogue of the inhibitory neurotransmitter GABA, which paradoxically is thought to not exert effects on GABA receptors. It appears to exert action via the alpha2-delta1 and alpha2-delta2 auxiliary subunits of voltage-gated calcium channels. It is as adjunctive therapy in the treatment of partial seizures.


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