Which medications in the drug class Anti-Inflammatory Agents are used in the treatment of Haemophilus Meningitis?

Updated: Jul 09, 2018
  • Author: Prateek Lohia, MD, MHA; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Answer

Anti-Inflammatory Agents

Anti-inflammatory therapy remains controversial, but dexamethasone may help prevent hearing loss. Administering the dexamethasone either before or concomitant with the first dose of antimicrobial therapy is likely of considerable importance if a positive effect is expected.

Dexamethasone (Baycadron, DexPak 10 Day, DexPak 13 Day, DexPak 6 Day)

Dexamethasone has many pharmacologic benefits but significant adverse effects. It stabilizes cell and lysosomal membranes, increases surfactant synthesis, increases serum vitamin A concentration, and inhibits prostaglandin and proinflammatory cytokines (eg, TNF-alpha, IL-6, IL-2, and IFN-gamma). The inhibition of chemotactic factors and factors that increase capillary permeability inhibits the recruitment of inflammatory cells into affected areas. If dexamethasone treatment is elected, the recommended dose is 0.15 mg/kg every 6 hours for the first 2 days after the initial diagnosis and treatment. In addition, care must be exerted to avoid complications such as gastrointestinal hemorrhage.


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