What is the role of CSF protein concentration in the workup of Haemophilus influenzae type b (Hib) meningitis?

Updated: Jul 09, 2018
  • Author: Prateek Lohia, MD, MHA; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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Answer

As happens with any process that disturbs the function of the blood-brain barrier, CSF protein concentrations increase in bacterial meningitis. In Hib meningitis, this value for lumbar CSF is typically greater than 50 mg/dL, with a typical range of 100-500 mg/dL. If ventricular CSF is available for analysis, note that protein values greater than 15 mg/dL are abnormal. In the event of a traumatic tap, protein values may be grossly estimated by subtracting 1 mg/dL of protein for every 1000 RBCs/µL.


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