Which drugs can cause chronic Addison disease?

Updated: Mar 11, 2020
  • Author: George T Griffing, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

Drug-related causes

  • Ketoconazole inhibits the adrenal cytochrome P450 steroidogenic enzymes.

  • Aminoglutethimide blocks the early conversion of cholesterol to pregnenolone by inhibiting the 20,22-desmolase enzyme.

  • Mitotane (O,P'-DDD) blocks adrenal mitochondrial steroid biosynthesis.

  • Busulphan, etomidate, and trilostane inhibit or interfere with adrenal steroid biosynthesis.

  • Methadone, perhaps by depleting pituitary ACTH, may cause secondary adrenocortical insufficiency in some patients. [37]


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