How do chronic granulomatous diseases cause chronic Addison disease?

Updated: Mar 11, 2020
  • Author: George T Griffing, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Chronic granulomatous diseases [17]

  • TB, sarcoidosis, histoplasmosis, blastomycosis, and cryptococcosis could involve the adrenal glands.

  • In the preantibiotic era, TB was the most common cause and still may be a major consideration in areas where TB is common. It tends to involve both the adrenal cortex and the medulla; however, medullary involvement may not have any major consequences.

  • TB of the adrenal glands usually is a tertiary disease due to the hematogenous spread of infection to the adrenal glands, but clinical evidence of the primary infection is not always present.

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