Which medications in the drug class Anesthetics are used in the treatment of Status Epilepticus?

Updated: Feb 13, 2018
  • Author: Julie L Roth, MD; Chief Editor: Stephen A Berman, MD, PhD, MBA  more...
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These agents stabilize the neuronal membrane so the neuron is less permeable to ions. This prevents the initiation and transmission of nerve impulses, thereby producing the local anesthetic effects. In SE, lidocaine is indicated for refractory cases only and its use is supported only by anecdotal reports. The consensus seems to be moving toward propofol or midazolam infusions for refractory status epilepticus.

Propofol (Diprivan)

A phenolic compound unrelated to other types of anticonvulsants, propofol has general anesthetic properties when administered IV. There are increasing anecdotal reports of its use in refractory status epilepticus. Intubation and ventilation are required. Hypotension may require treatment.

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