What is the prevalence of cerebral amyloid angiopathy (CAA) in the US?

Updated: Dec 19, 2018
  • Author: Ravi S Menon, MD; Chief Editor: Helmi L Lutsep, MD  more...
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Answer

Answer

The true incidence and prevalence of cerebral amyloid angiopathy (CAA) are hard to specify, as definite CAA is a pathologic diagnosis typically obtained postmortem. However, estimates can be made based on autopsy series and the incidence of lobar intracranial hemorrhage (ICH). A series of 400 autopsies found evidence of CAA in the brains of 18.3% of men and 28% of women aged 40-90 years.

In a series of 117 brains of patients with confirmed AD, 83% had evidence of CAA. [6] The prevalence of CAA increases with advancing age; some autopsy series have found CAA in 5% of individuals in the seventh decade but in 50% of those older than 90 years. In patients with Alzheimer disease (AD), the incidence in several studies and meta-analyses has ranged from about 80-90%.

CAA is estimated to account for up to 15% of all ICH in patients older than 60 years and up to one half of nontraumatic lobar ICH in patients older than 70 years (approximately 15-20 cases per 100,000 people annually). CAA and CAA-related hemorrhage are particularly common in elderly individuals with AD and Down syndrome.


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