What causes cerebral amyloid angiopathy (CAA)?

Updated: Dec 19, 2018
  • Author: Ravi S Menon, MD; Chief Editor: Helmi L Lutsep, MD  more...
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Most cases of cerebral amyloid angiopathy (CAA) are sporadic, although genetic predispositions exist; eg, apolipoprotein E (ApoE) subtypes confer different risk profiles.

Most cases of CAA-related intracranial hemorrhage (ICH) are spontaneous. However, some evidence suggests that the amyloid is produced in the smooth muscle cells of the tunica media as a response to damage to the vessel wall (perhaps by arteriosclerosis or hypertension). Hereditary forms of CAA are due to specific gene mutations.

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