Which conditions increase the risk for development of cerebral aneurysms?

Updated: Dec 06, 2018
  • Author: David S Liebeskind, MD, FAAN, FAHA, FANA; Chief Editor: Helmi L Lutsep, MD  more...
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The development of cerebral aneurysms remains a controversial topic. A multifactorial etiology is most likely, reflecting the interaction of environmental factors, such as atherosclerosis or hypertension, and a congenital predisposition associated with various vascular abnormalities. Abnormalities of the internal elastic lamina may be congenital or degenerative. Multiple conditions have been associated with cerebral aneurysms; they include the following:

  • Autosomal dominant inherited polycystic kidney disease

  • Fibromuscular dysplasia

  • Arteriovenous malformations

  • Osler-Weber-Rendu syndrome

  • Coarctation of the aorta

  • Other vascular anomalies

  • Moyamoya syndrome

  • Marfan syndrome

  • Ehlers-Danlos syndrome, type IV

  • Other collagen type III disorders

  • Pseudoxanthoma elasticum

  • Alpha1-antitrypsin deficiency

  • Systemic lupus erythematosus

  • Sickle cell anemia

  • Bacterial endocarditis

  • Fungal infections

  • Neurofibromatosis type 1

  • Tuberous sclerosis

Environmental stressors, such as hypertension, have been associated with the presence of multiple aneurysms. A familial inheritance pattern has been noted in fewer than 2% of intracranial aneurysms.

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