When is oral anticoagulation indicated for secondary stroke prevention?

Updated: Dec 18, 2018
  • Author: Salvador Cruz-Flores, MD, MPH, FAHA, FCCM, FAAN, FACP, FANA; Chief Editor: Helmi L Lutsep, MD  more...
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Other cardiac indications for oral anticoagulation for secondary stroke prevention may include the following:

  • Mitral valve prolapse with myxomatous leaflets (target INR 2.5, range 2-3; not evidence based)

  • Rupture of chordae tendineae (target INR 2.5, range 2-3)

  • Dyskinetic ventricular wall segment (target INR 2.5, range 2-3)

  • Mitral ring calcifications (target INR 2.5, range 2-3)

In patients with aortic atheromas identified on echocardiography, the ideal strategy for stroke prevention remains uncertain. Mixed outcomes have been reported for anticoagulation therapy; plaque stabilization with statins appears promising. Neither approach has been tested in randomized, controlled trials. [43]

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