Which anticoagulant is the most effective for stroke prevention in older patients with atrial fibrillation (AF)?

Updated: Dec 18, 2018
  • Author: Salvador Cruz-Flores, MD, MPH, FAHA, FCCM, FAAN, FACP, FANA; Chief Editor: Helmi L Lutsep, MD  more...
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The choice of warfarin versus aspirin for prophylaxis in older patients was addressed in the Birmingham Atrial Fibrillation Treatment of the Aged Study (BAFTA), and compared with aspirin, warfarin reduced the risk of major stroke, arterial embolism, or other intracranial hemorrhage (yearly risk, 1.8% vs 3.8%). In this study, 973 patients 75 years of age or older (mean age, 81.5 years) were randomized to receive warfarin to an INR of 2–3 or aspirin, 75 mg/day; follow-up was for a mean of 2.7 years. [36]

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