What are the stroke event rates by CHADS2 score in patients receiving warfarin anticoagulation?

Updated: Dec 18, 2018
  • Author: Salvador Cruz-Flores, MD, MPH, FAHA, FCCM, FAAN, FACP, FANA; Chief Editor: Helmi L Lutsep, MD  more...
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Answer

In a cohort of 796 patients with atrial fibrillation with a mean follow-up of 2.4 years, 70% were treated with warfarin. Among subjects not anticoagulated, the rate of embolic events increased significantly with increasing CHADS2 score. Event rates by CHADS2 score among those receiving warfarin versus those not anticoagulated were as follows:

  • CHADS2 score of 0: 1% versus 4.1%

  • CHADS2 score of 1: 0.6% versus 7.1%

  • CHADS2 score of 2: 0.5% versus 5.1%

  • CHADS2 score of 3: 2.4% versus 12.5%

  • CHADS2 score of 4 or greater: 2.9% versus 20%

These results support long-term anticoagulation with warfarin in subjects with a CHADS2 score of 2 or higher. [21]


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