Which medications in the drug class Corticosteroids are used in the treatment of Brain Metastasis?

Updated: Aug 01, 2018
  • Author: Victor Tse, MD, PhD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Answer

Corticosteroids

These agents reduce edema around tumor, frequently leading to symptomatic and objective improvement.

Dexamethasone (Active Injection D, Dexamethasone Intensol, DexPak, DoubleDex)

The postulated mechanisms of action of corticosteroids in brain tumors include reduction in vascular permeability, cytotoxic effects on tumors, inhibition of tumor formation, and decreased CSF production.

Prednisone (Deltasone, Rayos, Prednisone Intensol)

Used adjunctively with chemotherapeutic medications. Glucocorticosteroid; elicits mild mineralocorticoid activity and moderate anti-inflammatory effects; controls or prevents inflammation by controlling rate of protein synthesis, suppressing migration of polymorphonuclear leukocytes (PMNs) and fibroblasts, reversing capillary permeability, and stabilizing lysosomes at cellular level; in physiologic doses, corticosteroids are administered to replace deficient endogenous hormones; in larger (pharmacologic) doses, they decrease inflammation

Prednisolone (Pediapred, Orapred ODT, Millipred, Millipred DP, Veripred 20)

Used adjunctively with chemotherapeutic medication, reversing capillary permeability, and stabilizing lysosomes at cellular level; Coticosteroids also decrease inflammation.


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