Which medications in the drug class Anticonvulsants are used in the treatment of Brain Metastasis?

Updated: Aug 01, 2018
  • Author: Victor Tse, MD, PhD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Answer

Anticonvulsants

Anticonvulsants are employed in management of seizures presenting as complication of disease

Valproic acid (Depacon, Depakene, Depakote, Depakote ER, Depakote Sprinkles)

May increase levels of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in brain; may enhance or mimic action of GABA at postsynaptic receptor sites; may also inhibit sodium and calcium channelsUsed to control seizures, including generalized motor seizures and complex partial seizures

Levetiracetam (Keppra, Keppra XR, Roweepra, Spritam)

Antiepileptic mechanism unknown; may inhibit voltage-depedent N-type calcium channels; may bind to synaptic proteins that modulate neurotransmitter release; through displacement of negative modulators may facilitate GABA-ergic inhibitory transmission

Lorazepam (Ativan, Lorazepam Intensol)

A benzodiazepine.  A sedative hypnotic with short onset of effects and relatively long half-life. Increases the action of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain; May depress all levels of CNS, including limbic and reticular formation. Indicated for status epilepticus as complication of disease

Diazepam (Diastat, Diastat AcuDial, Diazepam Intensol, Valium)

A benzodiazepine.  Extremely lipid-soluble agent that quickly enters brain in first pass and often stops seizures in 1-2 min. Rapidly distributes to other stores of body fat. Increases the action of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain; Indicated for status epilepticus as complication of disease

Phenytoin (Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Infatabs)

Sodium transport inhibitor indicated for management of generalized motor seizures and complex partial seizures


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