Which medications in the drug class General Anesthetics, Systemic are used in the treatment of Brain Metastasis?

Updated: Aug 01, 2018
  • Author: Victor Tse, MD, PhD; Chief Editor: Nicholas Lorenzo, MD, MHA, CPE  more...
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Answer

General Anesthetics, Systemic

These agents stabilize the neuronal membrane so the neuron is less permeable to ions. This prevents the initiation and transmision of nerve impulses, thereby producing anesthetic effect

Propofol (Diprivan, Fresenius Propoven)

Propofol, an IV anesthetic agent, is active on the glutamate and GABA-A receptors, whereas benzodiazepines are active only against the GABA receptors. Only slightly soluble in water, but highly soluble in lipids. CNS penetration primarily depends on cerebral blood flow. Emergence from anesthesia is relatively fast, even with prolonged infusions. Causes global CNS depression, presumably through agonist actions of GABA receptors; Indicated for treatment of status epilepticus presenting as complication of disease


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